Scientific Papers

  • 2015

  • Wolf E, Reichart B: Commentary on "Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood" (by Harris et al.): tailoring donor pigs for xenotransplantation-how to find the right combination of genetic modifications? Xenotransplantation 2015;

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  • Weiss M, Kost B, Renner-Muller I, Wolf E, Mylonas I, Bruning A: Efavirenz Causes Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Endothelial Cells. Cardiovascular toxicology 2015;

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  • Rozman J, Rathkolb B, Neschen S, Fuchs H, Gailus-Durner V, Klingenspor M, Wolf E, Hrabe de Angelis M: Glucose tolerance tests for systematic screening of glucose homeostasis in mice. Current protocols in mouse biology 2015;5:65-84

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  • Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tonjes RR, Klymiuk N, Wolf E, Bornstein SR: Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2015;47:31-35

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  • Rathkolb B, Klempt M, Sabrautzki S, Michel D, Klaften M, Laufs J, Sedlmeier R, Hans W, Fuchs H, Muckenthaler MU, Horsch M, Campagna DR, Fleming M, Hrabe de Angelis M, Wolf E, Aigner B: Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2015;28:293-306

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  • Neschen S, Scheerer M, Seelig A, Huypens P, Schultheiss J, Wu M, Wurst W, Rathkolb B, Suhre K, Wolf E, Beckers J, Hrabe de Angelis M: Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice. Diabetes 2015;64:284-290

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  • Li S, Edlinger M, Saalfrank A, Flisikowski K, Tschukes A, Kurome M, Zakhartchenko V, Kessler B, Saur D, Kind A, Wolf E, Schnieke A, Flisikowska T: Viable pigs with a conditionally-activated oncogenic KRAS mutation. Transgenic research 2015;

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  • Kurome M, Kessler B, Wuensch A, Nagashima H, Wolf E: Nuclear transfer and transgenesis in the pig. Methods in molecular biology 2015;1222:37-59

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  • Kahle M, Schafer A, Seelig A, Schultheiss J, Wu M, Aichler M, Leonhardt J, Rathkolb B, Rozman J, Sarioglu H, Hauck SM, Ueffing M, Wolf E, Kastenmueller G, Adamski J, Walch A, Hrabe de Angelis M, Neschen S: High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice. Molecular metabolism 2015;4:39-50

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  • Demant M, Deutsch DR, Frohlich T, Wolf E, Arnold GJ: Proteome analysis of early lineage specification in bovine embryos. Proteomics 2015;15:688-701

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  • Bauersachs S, Wolf E: Uterine responses to the preattachment embryo in domestic ungulates: recognition of pregnancy and preparation for implantation. Annual review of animal biosciences 2015;3:489-511

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  • 2014

  • Zumbrennen-Bullough KB, Becker L, Garrett L, Holter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA: Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments. PloS one 2014;9:e98072

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  • Wuensch A, Baehr A, Bongoni AK, Kemter E, Blutke A, Baars W, Haertle S, Zakhartchenko V, Kurome M, Kessler B, Faber C, Abicht JM, Reichart B, Wanke R, Schwinzer R, Nagashima H, Rieben R, Ayares D, Wolf E, Klymiuk N: Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs. Transplantation 2014;97:138-147

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  • Wolf E, Braun-Reichhart C, Streckel E, Renner S: Genetically engineered pig models for diabetes research. Transgenic research 2014;23:27-38

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  • Stribl C, Samara A, Trumbach D, Peis R, Neumann M, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rathkolb B, Wolf E, Beckers J, Horsch M, Neff F, Kremmer E, Koob S, Reichert AS, Hans W, Rozman J, Klingenspor M, Aichler M, Walch AK, Becker L, Klopstock T, Glasl L, Holter SM, Wurst W, Floss T: Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43. The Journal of biological chemistry 2014;289:10769-10784

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  • Samans B, Yang Y, Krebs S, Sarode GV, Blum H, Reichenbach M, Wolf E, Steger K, Dansranjavin T, Schagdarsurengin U: Uniformity of nucleosome preservation pattern in Mammalian sperm and its connection to repetitive DNA elements. Developmental cell 2014;30:23-35

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  • Popken J, Koehler D, Brero A, Wuensch A, Guengoer T, Thormeyer T, Wolf E, Cremer T, Zakhartchenko V: Positional changes of a pluripotency marker gene during structural reorganization of fibroblast nuclei in cloned early bovine embryos. Nucleus 2014;5:542-554

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  • Popken J, Brero A, Koehler D, Schmid VJ, Strauss A, Wuensch A, Guengoer T, Graf A, Krebs S, Blum H, Zakhartchenko V, Wolf E, Cremer T: Reprogramming of fibroblast nuclei in cloned bovine embryos involves major structural remodeling with both striking similarities and differences to nuclear phenotypes of in vitro fertilized embryos. Nucleus 2014;5:555-589

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  • Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML, 3rd, Lewis BG, Eckhaus M, Reimann KA, Klymiuk N, Wolf E, Ayares D, Horvath KA: One-year heterotopic cardiac xenograft survival in a pig to baboon model. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014;14:488-489

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  • Li S, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Saur D, Kind A, Wolf E, Flisikowski K, Schnieke A: Dual fluorescent reporter pig for Cre recombination: transgene placement at the ROSA26 locus. PloS one 2014;9:e102455

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  • Kraus P, V S, Yu HB, Xing X, Lim SL, Adler T, Pimentel JA, Becker L, Bohla A, Garrett L, Hans W, Holter SM, Janas E, Moreth K, Prehn C, Puk O, Rathkolb B, Rozman J, Adamski J, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Neff F, Ollert M, Stoeger T, Yildrim AO, Eickelberg O, Wolf E, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Lufkin T, Stanton LW: Pleiotropic functions for transcription factor zscan10. PloS one 2014;9:e104568

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  • Klymiuk N, Fezert P, Wunsch A, Kurome M, Kessler B, Wolf E: Homologous recombination contributes to the repair of zinc-finger-nuclease induced double strand breaks in pig primary cells and facilitates recombination with exogenous DNA. Journal of biotechnology 2014;177:74-81

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  • Kemter E, Sklenak S, Rathkolb B, Hrabe de Angelis M, Wolf E, Aigner B, Wanke R: No amelioration of uromodulin maturation and trafficking defect by sodium 4-phenylbutyrate in vivo: studies in mouse models of uromodulin-associated kidney disease. The Journal of biological chemistry 2014;289:10715-10726

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  • Kemter E, Rathkolb B, Becker L, Bolle I, Busch DH, Dalke C, Elvert R, Favor J, Graw J, Hans W, Ivandic B, Kalaydjiev S, Klopstock T, Racz I, Rozman J, Schrewe A, Schulz H, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Aigner B: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice. Journal of biomedical science 2014;21:68

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  • Keller J, Catala-Lehnen P, Huebner AK, Jeschke A, Heckt T, Lueth A, Krause M, Koehne T, Albers J, Schulze J, Schilling S, Haberland M, Denninger H, Neven M, Hermans-Borgmeyer I, Streichert T, Breer S, Barvencik F, Levkau B, Rathkolb B, Wolf E, Calzada-Wack J, Neff F, Gailus-Durner V, Fuchs H, de Angelis MH, Klutmann S, Tsourdi E, Hofbauer LC, Kleuser B, Chun J, Schinke T, Amling M: Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts. Nature communications 2014;5:5215

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  • Grill JI, Neumann J, Herbst A, Hiltwein F, Ofner A, Marschall MK, Wolf E, Kirchner T, Goke B, Schneider MR, Kolligs FT: DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice. Molecular cancer research : MCR 2014;12:1655-1662

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  • Horsch M, Beckers J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rathkolb B, Wolf E, Aigner B, Kemter E: Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: renal transcriptome studies in mouse models of uromodulin-associated kidney disease. PloS one 2014;9:e113125

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  • Graf A, Krebs S, Zakhartchenko V, Schwalb B, Blum H, Wolf E: Fine mapping of genome activation in bovine embryos by RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America 2014;111:4139-4144

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  • Graf A, Krebs S, Heininen-Brown M, Zakhartchenko V, Blum H, Wolf E: Genome activation in bovine embryos: review of the literature and new insights from RNA sequencing experiments. Animal reproduction science 2014;149:46-58

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  • Friederichs S, Krebs S, Blum H, Wolf E, Lang H, von Buttlar H, Buttner M: Comparative and retrospective molecular analysis of Parapoxvirus (PPV) isolates. Virus research 2014;181:11-21

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  • Deutsch DR, Frohlich T, Otte KA, Beck A, Habermann FA, Wolf E, Arnold GJ: Stage-specific proteome signatures in early bovine embryo development. Journal of proteome research 2014;13:4363-4376

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  • Dahlhoff M, Wolf E, Schneider MR: The ABC of BTC: structural properties and biological roles of betacellulin. Seminars in cell & developmental biology 2014;28:42-48

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  • Dahlhoff M, Pfister S, Blutke A, Rozman J, Klingenspor M, Deutsch MJ, Rathkolb B, Fink B, Gimpfl M, Hrabe de Angelis M, Roscher AA, Wolf E, Ensenauer R: Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring. Biochimica et biophysica acta 2014;1842:304-317

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  • Bongoni AK, Kiermeir D, Jenni H, Bahr A, Ayares D, Klymiuk N, Wolf E, Voegelin E, Constantinescu MA, Seebach JD, Rieben R: Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood. Xenotransplantation 2014;21:230-243

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  • Blutke A, Schneider MR, Renner-Muller I, Herbach N, Wanke R, Wolf E: Genetic dissection of IGF1-dependent and -independent effects of permanent GH excess on postnatal growth and organ pathology of mice. Molecular and cellular endocrinology 2014;394:88-98

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  • Zadeh-Khorasani M, Nolte T, Mueller TD, Pechlivanis M, Rueff F, Wollenberg A, Fricker G, Wolf E, Siebeck M, Gropp R: NOD-scid IL2R gammanull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways. Journal of translational medicine 2013;11:4

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  • 2013

  • Wuensch A, Baehr A, Bongoni AK, Kemter E, Blutke A, Baars W, Haertle S, Zakhartchenko V, Kurome M, Kessler B, Faber C, Abicht JM, Reichart B, Wanke R, Schwinzer R, Nagashima H, Rieben R, Ayares D, Wolf E, Klymiuk N: Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-Specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic Pigs. Transplantation 2013;

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  • Wolf E, Braun-Reichhart C, Streckel E, Renner S: Genetically engineered pig models for diabetes research. Transgenic research 2013;

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  • Venit T, Dzijak R, Kalendova A, Kahle M, Rohozkova J, Schmidt V, Rulicke T, Rathkolb B, Hans W, Bohla A, Eickelberg O, Stoeger T, Wolf E, Yildirim AO, Gailus-Durner V, Fuchs H, de Angelis MH, Hozak P: Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus. PloS one 2013;8:e61406

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  • Sabrautzki S, Janas E, Lorenz-Depiereux B, Calzada-Wack J, Aguilar-Pimentel JA, Rathkolb B, Adler T, Cohrs C, Hans W, Diener S, Fuchs H, Gailus-Durner V, Busch DH, Hofler H, Ollert M, Strom TM, Wolf E, Neff F, Hrabe de Angelis M: An ENU mutagenesis-derived mouse model with a dominant Jak1 mutation resembling phenotypes of systemic autoimmune disease. The American journal of pathology 2013;183:352-368

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  • Renner S, Braun-Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E, Wunsch A, Kessler B, Kurome M, Bahr A, Klymiuk N, Krebs S, Puk O, Nagashima H, Graw J, Blum H, Wanke R, Wolf E: Permanent neonatal diabetes in INS(C94Y) transgenic pigs. Diabetes 2013;62:1505-1511

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  • Parzefall T, Shivatzki S, Lenz DR, Rathkolb B, Ushakov K, Karfunkel D, Shapira Y, Wolf M, Mohr M, Wolf E, Sabrautzki S, de Angelis MH, Frydman M, Brownstein Z, Avraham KB: Cytoplasmic mislocalization of POU3F4 due to novel mutations leads to deafness in humans and mice. Human mutation 2013;34:1102-1110

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  • Nolte T, Zadeh-Khorasani M, Safarov O, Rueff F, Gulberg V, Herbach N, Wollenberg A, Mueller T, Siebeck M, Wolf E, Gropp R: Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells. Clinical and experimental immunology 2013;172:349-362

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  • Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schroder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Holter SM, Moreth K, Prehn C, Puk O, Racz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Hofler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D: Rapamycin extends murine lifespan but has limited effects on aging. The Journal of clinical investigation 2013;123:3272-3291

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  • Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML, 3rd, Lewis BG, Eckhaus M, Reimann KA, Klymiuk N, Wolf E, Ayares D, Horvath KA: One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013;

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  • Lommel M, Winterhalter PR, Willer T, Dahlhoff M, Schneider MR, Bartels MF, Renner-Muller I, Ruppert T, Wolf E, Strahl S: Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion. Proceedings of the National Academy of Sciences of the United States of America 2013;110:21024-21029

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  • Kurome M, Geistlinger L, Kessler B, Zakhartchenko V, Klymiuk N, Wuensch A, Richter A, Baehr A, Kraehe K, Burkhardt K, Flisikowski K, Flisikowska T, Merkl C, Landmann M, Durkovic M, Tschukes A, Kraner S, Schindelhauer D, Petri T, Kind A, Nagashima H, Schnieke A, Zimmer R, Wolf E: Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set. BMC biotechnology 2013;13:43

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  • Kugler JE, Horsch M, Huang D, Furusawa T, Rochman M, Garrett L, Becker L, Bohla A, Holter SM, Prehn C, Rathkolb B, Racz I, Aguilar-Pimentel JA, Adler T, Adamski J, Beckers J, Busch DH, Eickelberg O, Klopstock T, Ollert M, Stoger T, Wolf E, Wurst W, Yildirim AO, Zimmer A, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Garfinkel B, Orly J, Ovcharenko I, Bustin M: High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner. The Journal of biological chemistry 2013;288:16690-16703

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  • Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Aartsma-Rus A, Thirion C, Lochmuller H, Walter MC, Wolf E: Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle. Human molecular genetics 2013;22:4368-4382

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  • Kemter E, Prueckl P, Sklenak S, Rathkolb B, Habermann FA, Hans W, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Wolf E, Aigner B, Wanke R: Type of uromodulin mutation and allelic status influence onset and severity of uromodulin-associated kidney disease in mice. Human molecular genetics 2013;22:4148-4163

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  • Kemter E, Pruckl P, Rathkolb B, Micklich K, Adler T, Becker L, Beckers J, Busch DH, Gotz AA, Hans W, Horsch M, Ivandic B, Klingenspor M, Klopstock T, Rozman J, Schrewe A, Schulz H, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Aigner B: Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice. PloS one 2013;8:e78337

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  • Kahle M, Horsch M, Fridrich B, Seelig A, Schultheiss J, Leonhardt J, Irmler M, Beckers J, Rathkolb B, Wolf E, Franke N, Gailus-Durner V, Fuchs H, de Angelis MH, Neschen S: Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis. Molecular metabolism 2013;2:435-446

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  • Ju L, Wing J, Taylor E, Brandt R, Slijepcevic P, Horsch M, Rathkolb B, Racz I, Becker L, Hans W, Adler T, Beckers J, Rozman J, Klingenspor M, Wolf E, Zimmer A, Klopstock T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, van der Horst G, Lehmann AR: SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities. DNA repair 2013;12:356-366

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  • Holter SM, Stromberg M, Kovalenko M, Garrett L, Glasl L, Lopez E, Guide J, Gotz A, Hans W, Becker L, Rathkolb B, Rozman J, Schrewed A, Klingenspor M, Klopstock T, Schulz H, Wolf E, Wursta W, Gillis T, Wakimoto H, Seidman J, MacDonald ME, Cotman S, Gailus-Durner V, Fuchs H, de Angelis MH, Lee JM, Wheeler VC: A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice. PloS one 2013;8:e80923

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  • Hochrath K, Ehnert S, Ackert-Bicknell CL, Lau Y, Schmid A, Krawczyk M, Hengstler JG, Dunn J, Hiththetiya K, Rathkolb B, Micklich K, Hans W, Fuchs H, Gailus-Durner V, Wolf E, de Angelis MH, Dooley S, Paigen B, Wildemann B, Lammert F, Nussler AK: Modeling hepatic osteodystrophy in Abcb4 deficient mice. Bone 2013;55:501-511

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  • Frohlich T, Kosters M, Graf A, Wolf E, Kobolak J, Brochard V, Dinnyes A, Jouneau A, Arnold GJ: iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells. Journal of proteomics 2013;90:38-51

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  • Flisikowski K, Boulhaeve M, Lopes FP, Wolf E, Zwierzchowski L: Expression pattern of STAT5A gene during early bovine embryogenesis. Zygote 2013:1-5

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  • Dahlhoff M, Schafer M, Wolf E, Schneider MR: Genetic deletion of the EGFR ligand epigen does not affect mouse embryonic development and tissue homeostasis. Experimental cell research 2013;319:529-535

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  • Dahlhoff M, Pfister S, Blutke A, Rozman J, Klingenspor M, Deutsch MJ, Rathkolb B, Fink B, Gimpfl M, Hrabe de Angelis M, Roscher AA, Wolf E, Ensenauer R: Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring. Biochimica et biophysica acta 2013;

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  • Dahlhoff M, Emrich D, Wolf E, Schneider MR: Increased activation of the epidermal growth factor receptor in transgenic mice overexpressing epigen causes peripheral neuropathy. Biochimica et biophysica acta 2013;1832:2068-2076

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  • Dahlhoff M, de Angelis MH, Wolf E, Schneider MR: Ligand-independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice. Experimental dermatology 2013;22:667-669

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  • Bongoni AK, Kiermeir D, Jenni H, Wunsch A, Bahr A, Ayares D, Seebach JD, Wolf E, Klymiuk N, Constantinescu MA, Vogelin E, Rieben R: Activation of the lectin pathway of complement in pig-to-human xenotransplantation models. Transplantation 2013;96:791-799

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  • Bebbere D, Bauersachs S, Furst RW, Reichenbach HD, Reichenbach M, Medugorac I, Ulbrich SE, Wolf E, Ledda S, Hiendleder S: Tissue-specific and minor inter-individual variation in imprinting of IGF2R is a common feature of Bos taurus Concepti and not correlated with fetal weight. PloS one 2013;8:e59564

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  • Bauersachs S, Wolf E: Immune aspects of embryo-maternal cross-talk in the bovine uterus. Journal of reproductive immunology 2013;97:20-26

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  • 2012

  • Walters EM, Wolf E, Whyte JJ, Mao J, Renner S, Nagashima H, Kobayashi E, Zhao J, Wells KD, Critser JK, Riley LK, Prather RS: Completion of the swine genome will simplify the production of swine as a large animal biomedical model. BMC medical genomics 2012;5:55

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  • van Buerck L, Schuster M, Rathkolb B, Sabrautzki S, Hrabe de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N: Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants. Molecular and cellular endocrinology 2012;362:139-148

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  • Ulbrich SE, Wolf E, Bauersachs S: Hosting the preimplantation embryo: potentials and limitations of different approaches for analysing embryo-endometrium interactions in cattle. Reproduction, fertility, and development 2012;25:62-70

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  • Streyl D, Kenngott R, Herbach N, Wanke R, Blum H, Sinowatz F, Wolf E, Zerbe H, Bauersachs S: Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in the release of foetal membranes. Reproduction 2012;143:85-105

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  • Stein C, Kling L, Proetzel G, Roopenian DC, de Angelis MH, Wolf E, Rathkolb B: Clinical chemistry of human FcRn transgenic mice. Mammalian genome : official journal of the International Mammalian Genome Society 2012;23:259-269

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  • Staropoli JF, Haliw L, Biswas S, Garrett L, Holter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM, Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, de Angelis MH, Cotman SL: Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system. PloS one 2012;7:e38310

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  • Schneider MR, Dahlhoff M, Andrukhova O, Grill J, Glosmann M, Schuler C, Weber K, Wolf E, Erben RG: Normal epidermal growth factor receptor signaling is dispensable for bone anabolic effects of parathyroid hormone. Bone 2012;50:237-244

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  • Sax G, Kessler B, Wolf E, Winter G: In-vivo biodegradation of extruded lipid implants in rabbits. Journal of controlled release : official journal of the Controlled Release Society 2012;163:195-202

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  • Sabrautzki S, Rubio-Aliaga I, Hans W, Fuchs H, Rathkolb B, Calzada-Wack J, Cohrs CM, Klaften M, Seedorf H, Eck S, Benet-Pages A, Favor J, Esposito I, Strom TM, Wolf E, Lorenz-Depiereux B, Hrabe de Angelis M: New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis. Mammalian genome : official journal of the International Mammalian Genome Society 2012;23:416-430

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  • Richter A, Kurome M, Kessler B, Zakhartchenko V, Klymiuk N, Nagashima H, Wolf E, Wuensch A: Potential of primary kidney cells for somatic cell nuclear transfer mediated transgenesis in pig. BMC biotechnology 2012;12:84

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  • Renner S, Romisch-Margl W, Prehn C, Krebs S, Adamski J, Goke B, Blum H, Suhre K, Roscher AA, Wolf E: Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced beta-cell mass. Diabetes 2012;61:2166-2175

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  • Pozzi B, Amodio S, Lucano C, Sciullo A, Ronzoni S, Castelletti D, Adler T, Treise I, Betsholtz IH, Rathkolb B, Busch DH, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Betsholtz C, Casola S, Di Fiore PP, Offenhauser N: The endocytic adaptor Eps15 controls marginal zone B cell numbers. PloS one 2012;7:e50818

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  • Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Stromberg S, Hans W, Klockars A, Alsio J, Riserus U, Becker L, Holter SM, Elvert R, Ehrhardt N, Gailus-Durner V, Fuchs H, Fredriksson R, Wolf E, Klopstock T, Wurst W, Levine AS, Marcus C, de Angelis MH, Klingenspor M, Schioth HB, Kilimann MW: Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans. PLoS genetics 2012;8:e1002568

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  • Nolte T, Zadeh-Khorasani M, Safarov O, Rueff F, Varga R, Herbach N, Wanke R, Wollenberg A, Mueller T, Gropp R, Wolf E, Siebeck M: Induction of oxazolone mediated features of atopic dermatitis in NOD-scid IL2R gammanull mice engrafted with human peripheral blood mononuclear cells. Disease models & mechanisms 2012;

    Link

  • Mohr H, Mohr CA, Schneider MR, Scrivano L, Adler B, Kraner-Schreiber S, Schnieke A, Dahlhoff M, Wolf E, Koszinowski UH, Ruzsics Z: Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo. PLoS pathogens 2012;8:e1002728

    Link

  • Leuchs S, Saalfrank A, Merkl C, Flisikowska T, Edlinger M, Durkovic M, Rezaei N, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Kind A, Wolf E, Schnieke A: Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. PloS one 2012;7:e43323

    Link

  • Klymiuk N, van Buerck L, Bahr A, Offers M, Kessler B, Wuensch A, Kurome M, Thormann M, Lochner K, Nagashima H, Herbach N, Wanke R, Seissler J, Wolf E: Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice. Diabetes 2012;61:1527-1532

    Link

  • Klymiuk N, Mundhenk L, Kraehe K, Wuensch A, Plog S, Emrich D, Langenmayer MC, Stehr M, Holzinger A, Kroner C, Richter A, Kessler B, Kurome M, Eddicks M, Nagashima H, Heinritzi K, Gruber AD, Wolf E: Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis. Journal of molecular medicine 2012;90:597-608

    Link

  • Klymiuk N, Bocker W, Schonitzer V, Bahr A, Radic T, Frohlich T, Wunsch A, Kessler B, Kurome M, Schilling E, Herbach N, Wanke R, Nagashima H, Mutschler W, Arnold GJ, Schwinzer R, Schieker M, Wolf E: First inducible transgene expression in porcine large animal models. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26:1086-1099

    Link

  • Kemter E, Lieke T, Kessler B, Kurome M, Wuensch A, Summerfield A, Ayares D, Nagashima H, Baars W, Schwinzer R, Wolf E: Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses. Xenotransplantation 2012;19:40-51

    Link

  • Kautz S, van Burck L, Schuster M, Wolf E, Wanke R, Herbach N: Early insulin therapy prevents beta cell loss in a mouse model for permanent neonatal diabetes (Munich Ins2(C95S)). Diabetologia 2012;55:382-391

    Link

  • Huttemann M, Lee I, Gao X, Pecina P, Pecinova A, Liu J, Aras S, Sommer N, Sanderson TH, Tost M, Neff F, Aguilar-Pimentel JA, Becker L, Naton B, Rathkolb B, Rozman J, Favor J, Hans W, Prehn C, Puk O, Schrewe A, Sun M, Hofler H, Adamski J, Bekeredjian R, Graw J, Adler T, Busch DH, Klingenspor M, Klopstock T, Ollert M, Wolf E, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Weissmann N, Doan JW, Bassett DJ, Grossman LI: Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26:3916-3930

    Link

  • Hokkanen S, Feldmann HM, Ding H, Jung CK, Bojarski L, Renner-Muller I, Schuller U, Kretzschmar H, Wolf E, Herms J: Lack of Pur-alpha alters postnatal brain development and causes megalencephaly. Human molecular genetics 2012;21:473-484

    Link

  • Hochrath K, Krawczyk M, Goebel R, Langhirt M, Rathkolb B, Micklich K, Rozman J, Horsch M, Beckers J, Klingenspor M, Fuchs H, Gailus-Durner V, Wolf E, Acalovschi M, Volmer DA, Hrabe de Angelis M, Lammert F: The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26:5081-5091

    Link

  • Fuchs H, Sabrautzki S, Seedorf H, Rathkolb B, Rozman J, Hans W, Schneider R, Klaften M, Holter SM, Becker L, Klempt M, Elvert R, Wurst W, Klopstock T, Klingenspor M, Wolf E, Gailus-Durner V, de Angelis MH: Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines. European journal of oral sciences 2012;120:269-277

    Link

  • Fuchs H, Gailus-Durner V, Neschen S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Bohla A, Calzada-Wack J, Cohrs C, Dewert A, Fridrich B, Garrett L, Glasl L, Gotz A, Hans W, Holter SM, Horsch M, Hurt A, Janas E, Janik D, Kahle M, Kistler M, Klein-Rodewald T, Lengger C, Ludwig T, Maier H, Marschall S, Micklich K, Moller G, Naton B, Prehn C, Puk O, Racz I, Rass M, Rathkolb B, Rozman J, Scheerer M, Schiller E, Schrewe A, Steinkamp R, Stoger C, Sun M, Szymczak W, Treise I, Vargas Panesso IL, Vernaleken AM, Willershauser M, Wolff-Muscate A, Zeh R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Eickelberg O, Favor J, Graw J, Hofler H, Hoschen C, Katus H, Klingenspor M, Klopstock T, Neff F, Ollert M, Schulz H, Stoger T, Wolf E, Wurst W, Yildirim AO, Zimmer A, Hrabe de Angelis M: Innovations in phenotyping of mouse models in the German Mouse Clinic. Mammalian genome : official journal of the International Mammalian Genome Society 2012;23:611-622

    Link

  • Flisikowski K, Venhoranta H, Bauersachs S, Hanninen R, Furst RW, Saalfrank A, Ulbrich SE, Taponen J, Lohi H, Wolf E, Kind A, Andersson M, Schnieke A: Truncation of MIMT1 gene in the PEG3 domain leads to major changes in placental gene expression and stillbirth in cattle. Biology of reproduction 2012;87:140

    Link

  • Flisikowska T, Merkl C, Landmann M, Eser S, Rezaei N, Cui X, Kurome M, Zakhartchenko V, Kessler B, Wieland H, Rottmann O, Schmid RM, Schneider G, Kind A, Wolf E, Saur D, Schnieke A: A porcine model of familial adenomatous polyposis. Gastroenterology 2012;143:1173-1175 e1171-1177

    Link

  • Dahlhoff M, Rose C, de Angelis MH, Wolf E, Schneider MR: Negative feedback mechanisms surpass the effect of intrinsic EGFR activation during skin chemical carcinogenesis. The American journal of pathology 2012;180:1378-1385

    Link

  • Dahlhoff M, Grzech M, Habermann FA, Wolf E, Schneider MR: A transgenic mouse line expressing cre recombinase in pancreatic beta-cells. Genesis 2012;50:437-442

    Link

  • Dahlhoff M, Gerhard M, Rad R, Linden S, Wolf E, Schneider MR: A new mouse model for studying EGFR-dependent gastric polyps. Biochimica et biophysica acta 2012;1822:1293-1299

    Link

  • Bauersachs S, Wolf E: Transcriptome analyses of bovine, porcine and equine endometrium during the pre-implantation phase. Animal reproduction science 2012;134:84-94

    Link

  • Bauersachs S, Ulbrich SE, Reichenbach HD, Reichenbach M, Buttner M, Meyer HH, Spencer TE, Minten M, Sax G, Winter G, Wolf E: Comparison of the effects of early pregnancy with human interferon, alpha 2 (IFNA2), on gene expression in bovine endometrium. Biology of reproduction 2012;86:46

    Link

  • Bahr A, Wolf E: Domestic animal models for biomedical research. Reproduction in domestic animals 2012;47 Suppl 4:59-71

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  • 2011

  • Abe, K., Fuchs, H., Boersma, A., Hans, W., Yu, P., Kalaydjiev, S., Klaften, M., Adler, T., Calzada-Wack, J., Mossbrugger, I., et al. (2011). A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cgamma2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model. Arthritis and rheumatism 63, 1301-1311.

    Link

  • Aigner, B., Rathkolb, B., Klempt, M., Wagner, S., Michel, D., Klaften, M., Laufs, J., Schneider, B., Sedlmeier, R., Hrabe de Angelis, M., et al. (2011). Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters. Mammalian genome : official journal of the International Mammalian Genome Society 22, 495-505.

    Link

  • Dahlhoff, M., Blutke, A., Wanke, R., Wolf, E., and Schneider, M.R. (2011). In vivo evidence for epidermal growth factor receptor (EGFR)-mediated release of prolactin from the pituitary gland. The Journal of biological chemistry 286, 39297-39306.

    Link

  • Dahlhoff, M., Rose, C., Wolf, E., and Schneider, M.R. (2011). Decreased incidence of papillomas in mice with impaired EGFR function during multi-stage skin carcinogenesis. Experimental dermatology 20, 290-293.

    Link

  • Fuchs, H., Gailus-Durner, V., Adler, T., Aguilar-Pimentel, J.A., Becker, L., Calzada-Wack, J., Da Silva-Buttkus, P., Neff, F., Gotz, A., Hans, W., et al. (2011). Mouse phenotyping. Methods 53, 120-135.

    Link

  • Groebner, A.E., Rubio-Aliaga, I., Schulke, K., Reichenbach, H.D., Daniel, H., Wolf, E., Meyer, H.H., and Ulbrich, S.E. (2011). Increase of essential amino acids in the bovine uterine lumen during preimplantation development. Reproduction 141, 685-695.

    Link

  • Groebner AE, Rubio-Aliaga I, Schulke K, Reichenbach HD, Daniel H, Wolf E, Meyer HH, Ulbrich SE. Increase of essential amino acids in the bovine uterine lumen during preimplantation development. Reproduction. 2011 Mar 7. [Epub ahead of print] PubMed PMID: 21383026.

    Link

  • Groebner, A.E., Schulke, K., Schefold, J.C., Fusch, G., Sinowatz, F., Reichenbach, H.D., Wolf, E., Meyer, H.H., and Ulbrich, S.E. (2011). Immunological mechanisms to establish embryo tolerance in early bovine pregnancy. Reproduction, fertility, and development 23, 619-632.

    Link

  • Groebner, A.E., Zakhartchenko, V., Bauersachs, S., Rubio-Aliaga, I., Daniel, H., Buttner, M., Reichenbach, H.D., Meyer, H.H., Wolf, E., and Ulbrich, S.E. (2011). Reduced amino acids in the bovine uterine lumen of cloned versus in vitro fertilized pregnancies prior to implantation. Cellular reprogramming 13, 403-410.

    Link

  • Herbach, N., Bergmayr, M., Goke, B., Wolf, E., and Wanke, R. (2011). Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice. PloS one 6, e22814.

    Link

  • Horsch, M., Seeburg, P.H., Adler, T., Aguilar-Pimentel, J.A., Becker, L., Calzada-Wack, J., Garrett, L., Gotz, A., Hans, W., Higuchi, M., et al. (2011). Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice. The Journal of biological chemistry 286, 18614-18622.

    Link

  • Lagutina, I., Zakhartchenko, V., Fulka, H., Colleoni, S., Wolf, E., Fulka, J., Jr., Lazzari, G., and Galli, C. (2011). Formation of nucleoli in interspecies nuclear transfer embryos derived from bovine, porcine, and rabbit oocytes and nuclear donor cells of various species. Reproduction 141, 453-465.

    Link

  • Larochelle, N., Stucka, R., Rieger, N., Schermelleh, L., Schiedner, G., Kochanek, S., Wolf, E., and Lochmuller, H. (2011). Genomic integration of adenoviral gene transfer vectors following transduction of fertilized mouse oocytes. Transgenic research 20, 123-135.

    Link

  • Leidenfrost, S., Boelhauve, M., Reichenbach, M., Gungor, T., Reichenbach, H.D., Sinowatz, F., Wolf, E., and Habermann, F.A. (2011). Cell arrest and cell death in mammalian preimplantation development: lessons from the bovine model. PloS one 6, e22121.

    Link

  • Pimentel, E.C., Bauersachs, S., Tietze, M., Simianer, H., Tetens, J., Thaller, G., Reinhardt, F., Wolf, E., and Konig, S. (2011). Exploration of relationships between production and fertility traits in dairy cattle via association studies of SNPs within candidate genes derived by expression profiling. Animal genetics 42, 251-262.

    Link

  • Raab, M., Kappel, S., Kramer, A., Sanhaji, M., Matthess, Y., Kurunci-Csacsko, E., Calzada-Wack, J., Rathkolb, B., Rozman, J., Adler, T., et al. (2011). Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells. Nature communications 2, 395.

    Link

  • Saarikangas, J., Mattila, P.K., Varjosalo, M., Bovellan, M., Hakanen, J., Calzada-Wack, J., Tost, M., Jennen, L., Rathkolb, B., Hans, W., et al. (2011). Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. Journal of cell science 124, 1245-1255.

    Link

  • Spyroglou, A., Wagner, S., Gomez-Sanchez, C., Rathkolb, B., Wolf, E., Manolopoulou, J., Reincke, M., Bidlingmaier, M., Hrabe de Angelis, M., and Beuschlein, F. (2011). Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism. Endocrinology 152, 326-331.

    Link

  • Ulbrich, S.E., Meyer, S.U., Zitta, K., Hiendleder, S., Sinowatz, F., Bauersachs, S., Buttner, M., Frohlich, T., Arnold, G.J., Reichenbach, H.D., et al. (2011). Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy. Molecular and cellular endocrinology 332, 48-57.

    Link

  • Zakhartchenko, V., Flisikowska, T., Li, S., Richter, T., Wieland, H., Durkovic, M., Rottmann, O., Kessler, B., Gungor, T., Brem, G., et al. (2011). Cell-mediated transgenesis in rabbits: chimeric and nuclear transfer animals. Biology of reproduction 84, 229-237.

    Link

  • 2010

  • Fuchs H, Gailus-Durner V, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Da Silva-Buttkus P, Neff F, Götz A, Hans W, Hölter SM, Horsch M, Kastenmüller G, Kemter E, Lengger C, Maier H, Matloka M, Möller G, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Römisch-Margl W, Rozman J, Wang-Sattler R, Schrewe A, Stöger C, Tost M, Adamski J, Aigner B, Beckers J, Behrendt H, Busch DH, Esposito I, Graw J, Illig T, Ivandic B, Klingenspor M, Klopstock T, Kremmer E, Mempel M, Neschen S, Ollert M, Schulz H, Suhre K, Wolf E, Wurst W, Zimmer A, HrabÄ› de Angelis M. Mouse phenotyping. Methods. 2011 Feb;53(2):120-35. Epub 2010 Aug 12. PubMed PMID: 20708688.

    Link

  • Ulbrich SE, Meyer SU, Zitta K, Hiendleder S, Sinowatz F, Bauersachs S, Büttner M, Fröhlich T, Arnold GJ, Reichenbach HD, Wolf E, Meyer HH. Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy. Mol Cell Endocrinol. 2011 Jan 30;332(1-2):48-57. Epub 2010 Sep 29. PubMed PMID: 20887771.

    Link

  • Pimentel EC, Bauersachs S, Tietze M, Simianer H, Tetens J, Thaller G, Reinhardt F, Wolf E, König S. Exploration of relationships between production and fertility traits in dairy cattle via association studies of SNPs within candidate genes derived by expression profiling. Anim Genet. 2010 Dec 30. doi: 10.1111/j.1365-2052.2010.02148.x. [Epub ahead of print] PubMed PMID: 21198698.

    Link

  • Schneider MR, Dahlhoff M, Horst D, Hirschi B, Trülzsch K, Müller-Höcker J, Vogelmann R, Allgäuer M, Gerhard M, Steininger S, Wolf E, Kolligs FT. A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. PLoS One. 2010 Dec 14;5(12):e14325. PubMed PMID: 21179475; PubMed Central PMCID: PMC3001873.

    Link

  • Shimizu T, Krebs S, Bauersachs S, Blum H, Wolf E, Miyamoto A. Actions and interactions of progesterone and estrogen on transcriptome profiles of the bovine endometrium. Physiol Genomics. 2010 Nov 29;42A(4):290-300. Epub 2010 Sep 28. PubMed PMID: 20876846.

    Link

  • Koehler D, Zakhartchenko V, Ketterl N, Wolf E, Cremer T, Brero A. FISH on 3D preserved bovine and murine preimplantation embryos. Methods Mol Biol. 2010;659:437-45. PubMed PMID: 20809333.

    Link

  • de Montera B, El Zeihery D, Müller S, Jammes H, Brem G, Reichenbach HD, Scheipl F, Chavatte-Palmer P, Zakhartchenko V, Schmitz OJ, Wolf E, Renard JP, Hiendleder S. Quantification of leukocyte genomic 5-methylcytosine levels reveals epigenetic plasticity in healthy adult cloned cattle. Cell Reprogram. 2010 Apr;12(2):175-81. PubMed PMID: 20677931; PubMed Central PMCID: PMC2993042.

    Link

  • Merkl M, Ulbrich SE, Otzdorff C, Herbach N, Wanke R, Wolf E, Handler J, Bauersachs S. Microarray analysis of equine endometrium at days 8 and 12 of pregnancy. Biol Reprod. 2010 Nov;83(5):874-86. Epub 2010 Jul 14. PubMed PMID: 20631402.

    Link

  • Dahlhoff M, Siegmund A, Golub Y, Wolf E, Holsboer F, Wotjak CT. AKT/GSK-3beta/beta-catenin signalling within hippocampus and amygdala reflects genetically determined differences in posttraumatic stress disorder like symptoms. Neuroscience. 2010 Sep 1;169(3):1216-26. Epub 2010 Jun 2. PubMed PMID: 20576499.

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  • Østrup E, Bauersachs S, Blum H, Wolf E, Hyttel P. Differential endometrial gene expression in pregnant and nonpregnant sows. Biol Reprod. 2010 Aug 1;83(2):277-85. Epub 2010 Apr 14. PubMed PMID: 20393170.

    Link

  • Aigner B, Renner S, Kessler B, Klymiuk N, Kurome M, Wünsch A, Wolf E. Transgenic pigs as models for translational biomedical research. J Mol Med. 2010 Jul;88(7):653-64. Epub 2010 Mar 26. Review. PubMed PMID: 20339830.

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  • Kemter E, Rathkolb B, Bankir L, Schrewe A, Hans W, Landbrecht C, Klaften M, Ivandic B, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Wolf E, Wanke R, Aigner B. Mutation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia. Am J Physiol Renal Physiol. 2010 Jun;298(6):F1405-15. Epub 2010 Mar 10. PubMed PMID: 20219826.

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  • Tocchetti A, Soppo CB, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J, Elvert R, Ehrhardt N, Rathkolb B, Moerth C, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Klingenspor M, Wolf E, Hrabé de Angelis M, Scanziani E, Tacchetti C, Scita G, Di Fiore PP, Offenhäuser N. Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. PLoS One. 2010 Mar 2;5(3):e9468. PubMed PMID: 20209148; PubMed Central PMCID: PMC2830459.

    Link

  • Renner S, Fehlings C, Herbach N, Hofmann A, von Waldthausen DC, Kessler B, Ulrichs K, Chodnevskaja I, Moskalenko V, Amselgruber W, Göke B, Pfeifer A, Wanke R, Wolf E. Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes. 2010 May;59(5):1228-38. Epub 2010 Feb 25. PubMed PMID: 20185813; PubMed Central PMCID: PMC2857903.

    Link

  • Mitterhuemer S, Petzl W, Krebs S, Mehne D, Klanner A, Wolf E, Zerbe H, Blum H. Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland. BMC Genomics. 2010 Feb 25;11:138. PubMed PMID: 20184744; PubMed Central PMCID: PMC2846913.

    Link

  • Groebner AE, Schulke K, Unterseer S, Reichenbach HD, Reichenbach M, Büttner M, Wolf E, Meyer HH, Ulbrich SE. Enhanced proapoptotic gene expression of XAF1, CASP8 and TNFSF10 in the bovine endometrium during early pregnancy is not correlated with augmented apoptosis. Placenta. 2010 Mar;31(3):168-77. Epub 2010 Jan 25. PubMed PMID: 20092891.

    Link

  • Aigner B, Klymiuk N, Wolf E. Transgenic pigs for xenotransplantation: selection of promoter sequences for reliable transgene expression. Curr Opin Organ Transplant. 2010 Apr;15(2):201-6. Review. PubMed PMID: 20061949.

    Link

  • Dahlhoff M, Algül H, Siveke JT, Lesina M, Wanke R, Wartmann T, Halangk W, Schmid RM, Wolf E, Schneider MR. Betacellulin protects from pancreatitis by activating stress-activated protein kinase. Gastroenterology. 2010 Apr;138(4):1585-94, 1594.e1-3. Epub 2009 Dec 29. PubMed PMID: 20038432.

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  • Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Rácz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J, Kunder S, Naton B, Gailus-Durner V, Fuchs H, Schulz H, Beckers J, Busch DH, Burbach JP, Smidt MP, Quintanilla-Martinez L, Esposito I, Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W, Zimmer A, de Angelis MH, Atkinson M, Heinzmann U, Graw J. Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mamm Genome. 2010 Feb;21(1-2):13-27. Epub 2009 Dec 22. PubMed PMID: 20033184.

    Link

  • Klymiuk N, Aigner B, Brem G, Wolf E. Genetic modification of pigs as organ donors for xenotransplantation. Mol Reprod Dev. 2010 Mar;77(3):209-21. Review. PubMed PMID: 19998476.

    Link

  • Ulbrich SE, Zitta K, Hiendleder S, Wolf E. In vitro systems for intercepting early embryo-maternal cross-talk in the bovine oviduct. Theriogenology. 2010 Apr 1;73(6):802-16. Epub 2009 Dec 5. Review. PubMed PMID: 19963260.

    Link

  • Schneider MR, Wolf E, Braun J, Kolb HJ, Adler H. Canine embryonic stem cells: state of the art. Theriogenology. 2010 Sep 1;74(4):492-7. Epub 2009 Dec 5. Review. PubMed PMID: 19963261.

    Link

  • van Bürck L, Blutke A, Kautz S, Rathkolb B, Klaften M, Wagner S, Kemter E, Hrabé de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N. Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2). Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E512-23. Epub 2009 Dec 1. PubMed PMID: 19952346.

    Link

  • Schneider MR, Gratao AA, Dahlhoff M, Boersma A, Hrabé de Angelis M, Hoang-Vu C, Wolf E, Klonisch T. EGFR ligands exert diverging effects on male reproductive organs. Exp Mol Pathol. 2010 Feb;88(1):216-8. Epub 2009 Nov 25. PubMed PMID: 19931240.

    Link

  • Reichenbach M, Lim T, Reichenbach HD, Guengoer T, Habermann FA, Matthiesen M, Hofmann A, Weber F, Zerbe H, Grupp T, Sinowatz F, Pfeifer A, Wolf E. Germ-line transmission of lentiviral PGK-EGFP integrants in transgenic cattle: new perspectives for experimental embryology. Transgenic Res. 2010 Aug;19(4):549-56. Epub 2009 Oct 28. PubMed PMID: 19862638.

    Link

  • Dahlhoff M, Müller AK, Wolf E, Werner S, Schneider MR. Epigen transgenic mice develop enlarged sebaceous glands. J Invest Dermatol. 2010 Feb;130(2):623-6. Epub 2009 Aug 20. PubMed PMID: 19693025.

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  • 2009

  • Grzech M, Dahlhoff M, Herbach N, Habermann FA, Renner-Müller I, Wanke R, Flaswinkel H, Wolf E, Schneider MR. Specific transgene expression in mouse pancreatic beta-cells under the control of the porcine insulin promoter. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):219-24. Epub 2009 Aug 12. PubMed PMID: 19682540.

    Link

  • Kemter E, Rathkolb B, Rozman J, Hans W, Schrewe A, Landbrecht C, Klaften M, Ivandic B, Fuchs H, Gailus-Durner V, Klingenspor M, de Angelis MH, Wolf E, Wanke R, Aigner B. Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1391-8. Epub 2009 Aug 19. PubMed PMID: 19692485.

    Link

  • Rathkolb B, Noyes HA, Brass A, Dark P, Fuchs H, Gailus-Durner V, Gibson J, de Angelis MH, Ogugo M, Iraqi F, Kemp SJ, Naessens J, Pope ME, Wolf E, Agaba M. Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection. Infect Immun. 2009 Sep;77(9):3948-57. Epub 2009 Jul 13. PubMed PMID: 19596769; PubMed Central PMCID: PMC2738039.

    Link

  • Rubio-Aliaga I, Przemeck GK, Fuchs H, Gailus-Durner V, Adler T, Hans W, Horsch M, Rathkolb B, Rozman J, Schrewe A, Wagner S, Hoelter SM, Becker L, Klopstock T, Wurst W, Wolf E, Klingenspor M, Ivandic BT, Busch DH, Beckers J, Hrabé de Angelis M. Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. PLoS One. 2009 Jun 29;4(6):e6054. PubMed PMID: 19562077; PubMed Central PMCID: PMC2699037.

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  • Brero A, Hao R, Schieker M, Wierer M, Wolf E, Cremer T, Zakhartchenko V. Reprogramming of active and repressive histone modifications following nuclear transfer with rabbit mesenchymal stem cells and adult fibroblasts. Cloning Stem Cells. 2009 Jun;11(2):319-29. PubMed PMID: 19508112.

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  • Aigner B, Rathkolb B, Klempt M, Wagner S, Michel D, de Angelis MH, Wolf E. N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels. J Biomed Sci. 2009 Jun 8;16:53. PubMed PMID: 19505327; PubMed Central PMCID: PMC2697975.

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  • Ulbrich SE, Frohlich T, Schulke K, Englberger E, Waldschmitt N, Arnold GJ, Reichenbach HD, Reichenbach M, Wolf E, Meyer HH, Bauersachs S. Evidence for estrogen-dependent uterine serpin (SERPINA14) expression during estrus in the bovine endometrial glandular epithelium and lumen. Biol Reprod. 2009 Oct;81(4):795-805. Epub 2009 Jun 3. PubMed PMID: 19494250.

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  • Bielohuby M, Roemmler J, Manolopoulou J, Johnsen I, Sawitzky M, Schopohl J, Reincke M, Wolf E, Hoeflich A, Bidlingmaier M. Chronic growth hormone excess is associated with increased aldosterone: a study in patients with acromegaly and in growth hormone transgenic mice. Exp Biol Med (Maywood). 2009 Aug;234(8):1002-9. Epub 2009 Jun 2. PubMed PMID: 19491373.

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  • Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Mossbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, de Angelis MH, Fischer J, Schwarz J, Pääbo S. A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell. 2009 May 29;137(5):961-71. PubMed PMID: 19490899.

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  • Puk O, Esposito I, Söker T, Löster J, Budde B, Nürnberg P, Michel-Soewarto D, Fuchs H, Wolf E, Hrabé de Angelis M, Graw J. A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease? Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4311-8. Epub 2009 Apr 30. PubMed PMID: 19407009.

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  • Dieckhoff B, Kessler B, Jobst D, Kues W, Petersen B, Pfeifer A, Kurth R, Niemann H, Wolf E, Denner J. Distribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation. Xenotransplantation. 2009 Mar-Apr;16(2):64-73. PubMed PMID: 19392721.

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  • Noyes HA, Alimohammadian MH, Agaba M, Brass A, Fuchs H, Gailus-Durner V, Hulme H, Iraqi F, Kemp S, Rathkolb B, Wolf E, de Angelis MH, Roshandel D, Naessens J. Mechanisms controlling anaemia in Trypanosoma congolense infected mice. PLoS One. 2009;4(4):e5170. Epub 2009 Apr 13. PubMed PMID: 19365556; PubMed Central PMCID: PMC2664899.

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  • Klonisch T, Glogowska A, Gratao AA, Grzech M, Nistor A, Torchia M, Weber E, de Angelis MH, Rathkolb B, Cuong HV, Wolf E, Schneider MR. The C-terminal cytoplasmic domain of human proEGF is a negative modulator of body and organ weights in transgenic mice. FEBS Lett. 2009 Apr 17;583(8):1349-57. Epub 2009 Mar 27. PubMed PMID: 19328792.

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  • Pflanz H, Vana K, Mitteregger G, Renner-Müller I, Pace C, Küchenhoff H, Kretzschmar HA, Wolf E, Weiss S. Scrapie-infected transgenic mice expressing a laminin receptor decoy mutant reveal a prolonged incubation time associated with low levels of PrPres. J Mol Biol. 2009 May 15;388(4):721-9. Epub 2009 Mar 24. PubMed PMID: 19324055.

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  • Bauersachs S, Ulbrich SE, Zakhartchenko V, Minten M, Reichenbach M, Reichenbach HD, Blum H, Spencer TE, Wolf E. The endometrium responds differently to cloned versus fertilized embryos. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5681-6. Epub 2009 Mar 23. PubMed PMID: 19307558; PubMed Central PMCID: PMC2666995.

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  • Siegmund A, Dahlhoff M, Habersetzer U, Mederer A, Wolf E, Holsboer F, Wotjak CT. Maternal inexperience as a risk factor of innate fear and PTSD-like symptoms in mice. J Psychiatr Res. 2009 Sep;43(14):1156-65. Epub 2009 Mar 21. PubMed PMID: 19304295.

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  • Gailus-Durner V, Fuchs H, Adler T, Aguilar Pimentel A, Becker L, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Ferwagner B, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Mörth C, Mossbrugger I, Naton B, Prehn C, Puk O, Rathkolb B, Rozman J, Schrewe A, Thiele F, Adamski J, Aigner B, Behrendt H, Busch DH, Favor J, Graw J, Heldmaier G, Ivandic B, Katus H, Klingenspor M, Klopstock T, Kremmer E, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, de Angelis MH. Systemic first-line phenotyping. Methods Mol Biol. 2009;530:463-509. PubMed PMID: 19266331.

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  • Koehler D, Zakhartchenko V, Froenicke L, Stone G, Stanyon R, Wolf E, Cremer T, Brero A. Changes of higher order chromatin arrangements during major genome activation in bovine preimplantation embryos. Exp Cell Res. 2009 Jul 15;315(12):2053-63. Epub 2009 Feb 28. PubMed PMID: 19254712.

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  • Herbach N, Schairer I, Blutke A, Kautz S, Siebert A, Göke B, Wolf E, Wanke R. Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. Am J Physiol Renal Physiol. 2009 Apr;296(4):F819-29. Epub 2009 Feb 11. PubMed PMID: 19211686.

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  • Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Mossbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M. The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Curr Pharm Biotechnol. 2009 Feb;10(2):236-43. PubMed PMID: 19199957.

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  • Aigner B, Rathkolb B, Klaften M, Sedlmeier R, Klempt M, Wagner S, Michel D, Mayer U, Klopstock T, de Angelis MH, Wolf E. Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models. Exp Physiol. 2009 Apr;94(4):412-21. Epub 2009 Jan 16. PubMed PMID: 19151073.

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  • Diehl D, Hessel E, Oesterle D, Renner-Müller I, Elmlinger M, Langhammer M, Göttlicher M, Wolf E, Lahm H, Hoeflich A. IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis. Int J Cancer. 2009 May 1;124(9):2220-5. PubMed PMID: 19142966.

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  • Berendt FJ, Fröhlich T, Bolbrinker P, Boelhauve M, Güngör T, Habermann FA, Wolf E, Arnold GJ. Highly sensitive saturation labeling reveals changes in abundance of cell cycle-associated proteins and redox enzyme variants during oocyte maturation in vitro. Proteomics. 2009 Feb;9(3):550-64. PubMed PMID: 19137544.

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  • Weiss EH, Lilienfeld BG, Müller S, Müller E, Herbach N, Kessler B, Wanke R, Schwinzer R, Seebach JD, Wolf E, Brem G. HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity. Transplantation. 2009 Jan 15;87(1):35-43. PubMed PMID: 19136889.

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  • Söker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, Favor J, Hans W, Hölter SM, Horsch M, Kallnik M, Kling E, Moerth C, Schrewe A, Stigloher C, Topp S, Gailus-Durner V, Naton B, Beckers J, Fuchs H, Ivandic B, Klopstock T, Schulz H, Wolf E, Wurst W, Bally-Cuif L, de Angelis MH, Graw J. Pleiotropic effects in Eya3 knockout mice. BMC Dev Biol. 2008 Dec 22;8:118. PubMed PMID: 19102749; PubMed Central PMCID: PMC2653502.

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  • Dahlhoff M, Dames PM, Lechner A, Herbach N, van Bürck L, Wanke R, Wolf E, Schneider MR. Betacellulin overexpression in transgenic mice improves glucose tolerance and enhances insulin secretion by isolated islets in vitro. Mol Cell Endocrinol. 2009 Feb 27;299(2):188-93. Epub 2008 Nov 28. PubMed PMID: 19100309.

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  • Schneider MR, Mayer-Roenne B, Dahlhoff M, Proell V, Weber K, Wolf E, Erben RG. High cortical bone mass phenotype in betacellulin transgenic mice is EGFR dependent. J Bone Miner Res. 2009 Mar;24(3):455-67. PubMed PMID: 19049329.

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  • Schneider MR, Wolf E. The epidermal growth factor receptor ligands at a glance. J Cell Physiol. 2009 Mar;218(3):460-6. Review. PubMed PMID: 19006176.

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  • Bielohuby M, Sawitzky M, Johnsen I, Wittenburg D, Beuschlein F, Wolf E, Hoeflich A. Decreased p44/42 mitogen-activated protein kinase phosphorylation in gender- or hormone-related but not during age-related adrenal gland growth in mice. Endocrinology. 2009 Mar;150(3):1269-77. Epub 2008 Oct 23. PubMed PMID: 18948401.

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  • Scientific Papers published before 2009

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